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Article

Chemical carcinogenesis: too many rodent carcinogens.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990

Ames B N, Gold L S

Abstract excerpt

The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude...

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Identifiers

PMID: 2217209
DOI: 10.1073/pnas.87.19.7772
PMCID: PMC54830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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