Article
Chemical carcinogenesis: too many rodent carcinogens.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Ames B N, Gold L S
Abstract excerpt
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high propo...
Topics
- Animals
- Carcinogenicity Tests
- Carcinogens
- Cell Division
- Dose-Response Relationship, Drug
- Humans
- Mice
- Mitogens
- Mutagenicity Tests
- Mutation
- Neoplasms
- Rats
- Risk Factors