Article
Identification and characterization of the conserved nucleoside-binding sites in the Epstein-Barr virus thymidine kinase.
The Biochemical journal - 1 May 2004
Wu Chung-Chun, Chen Min-Che, Chang Ya-Ru, Hsu Tsuey-Ying, Chen Jen-Yang
Abstract excerpt
Thymidine kinase (TK), encoded by EBV (Epstein-Barr virus), is an attractive target for antiviral therapy and provides a novel approach to the treatment of EBV-associated malignancies. Despite the extensive use of nucleoside analogues for the treatment of viral infections and cancer, the structure-function relationship of EBV TK has been addressed rarely. In the absence of any structural information, we sought to...
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