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Article

Kinetic studies of the predicted substrate-binding site of varicella-zoster virus thymidine kinase.

The Journal of general virology - 1 Jun 1993

Suzutani T, Davies L C, Honess R W

Abstract excerpt

To investigate the mechanism of kinetic action and substrate recognition of varicella-zoster virus (VZV) thymidine kinase (TK), we designed and isolated a site-directed mutant VZV TK which has double amino acid substitutions, 136threonine to leucine and 137isoleucine to leucine (SDM TK). This mutant was designed to alter the substrate-binding site of the VZV TK to duplicate that of the herpes simplex virus type 2...

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PMID: 8389797
DOI: 10.1099/0022-1317-74-6-1011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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