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Article

The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis.

The Journal of biological chemistry - 11 Sept 2009

Freeman Lucy, Buisson Marlyse, Tarbouriech Nicolas, Van der Heyden Angéline, Labbé Pierre, Burmeister Wim P

Abstract excerpt

Deoxyuridine 5'-triphosphate pyrophosphatases (dUTPases) are ubiquitous enzymes essential for hydrolysis of dUTP, thus preventing its incorporation into DNA. Although Epstein-Barr virus (EBV) dUTPase is monomeric, it has a high degree of similarity with the more frequent trimeric form of the enzyme. In both cases, the active site is composed of five conserved sequence motifs. Structural and functional studies of...

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Identifiers

PMID: 19586911
DOI: 10.1074/jbc.M109.019315
PMCID: PMC2757230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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