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Article

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

BMC structural biology - 24 Oct 2006

El Omari Kamel, Solaroli Nicola, Karlsson Anna, Balzarini Jan, Stammers David K

Abstract excerpt

BACKGROUND: Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of nucleoside analogues by virus-encoded thymidine (dThd) kinases (TK) represents one of the most successful strategies for antiviral chemotherapy as demonstrated for anti-herpes drugs. Vaccinia virus TK is a close orthologue of...

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Identifiers

PMID: 17062140
DOI: 10.1186/1472-6807-6-22
PMCID: PMC1636055

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