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Article

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.

Molecular pharmacology - 1 Jun 2006

El Omari Kamel, Liekens Sandra, Bird Louise E, Balzarini Jan, Stammers David K

Abstract excerpt

Varicella zoster virus encodes a thymidine kinase responsible for the activation of antiherpetic nucleoside prodrugs such as acyclovir. In addition, herpes virus thymidine kinases are being explored in gene/chemotherapy strategies aimed at developing novel antitumor therapies. To investigate and improve compound selectivity, we report here structure-based site-directed mutagenesis studies of varicella zoster...

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Identifiers

PMID: 16556772
DOI: 10.1124/mol.106.023002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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