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Article

Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.

Proteins - 1 Dec 2000

Vogt J, Perozzo R, Pautsch A, Prota A, Schelling P, Pilger B, Folkers G, Scapozza L, Schulz G E

Abstract excerpt

The crystal structures of the full-length Herpes simplex virus type 1 thymidine kinase in its unligated form and in a complex with an adenine analogue have been determined at 1.9 A resolution. The unligated enzyme contains four water molecules in the thymidine pocket and reveals a small induced f...

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Source

Identifiers

PMID: 11056041
DOI: 10.1002/1097-0134(20001201)41:4<545::aid-prot110>3.0.co;2-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11056041-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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