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Article

Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1.

The FEBS journal - 1 May 2012

Skovgaard Tine, Uhlin Ulla, Munch-Petersen Birgitte

Abstract excerpt

The first step for the intracellular retention of several anticancer or antiviral nucleoside analogues is the addition of a phosphate group catalysed by a deoxyribonucleoside kinase such as thymidine kinase 1 (TK1). Recently, human TK1 (HuTK1) has been crystallized and characterized using different ligands. To improve our understanding of TK1 substrate specificity, we performed a detailed, mutation-based...

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Identifiers

PMID: 22385435
DOI: 10.1111/j.1742-4658.2012.08554.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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