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Article

Folate binding site of flavin-dependent thymidylate synthase

10 Sept 2012

Abstract excerpt

The DNA nucleotide thymidylate is synthesized by the enzyme thymidylate synthase, which catalyzes the reductive methylation of deoxyuridylate using the cofactor methylene-tetrahydrofolate (CH(2)H(4)folate). Most organisms, including humans, rely on the thyA- or TYMS-encoded classic thymidylate synthase, whereas, certain microorganisms, including all Rickettsia and other pathogens, use an alternative thyX-encoded...

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Biochemical and Molecular Research
Enzyme Structure and Function
Folate and B Vitamins Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23019356
DOI: 10.1073/pnas.1206077109

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