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Article

Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched.

Mechanisms of development - 1 Jan 2000

Kagey Jacob D, Brown Jordan A, Moberg Kenneth H

Abstract excerpt

The Hedgehog (Hh) pathway was first defined by its role in segment polarity in the Drosophila melanogaster embryonic epidermis and has since been linked to many aspects of vertebrate development and disease. In humans, mutation of the Patched1 (PTCH1) gene, which encodes an inhibitor of Hh signaling, leads to tumors of the skin and pediatric brain. Despite the high level of conservation between the vertebrate and...

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Source

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Identifiers

PMID: 22705500
DOI: 10.1016/j.mod.2012.05.007
PMCID: PMC3668547

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched.PMID 22705500Read ↗

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