Article
ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin.
Journal of lipid research - 1 Apr 2004
Kajinami Kouji, Brousseau Margaret E, Nartsupha Chorthip, Ordovas Jose M, Schaefer Ernst J
Abstract excerpt
The mechanisms responsible for interindividual variation in response to statin therapy remain uncertain. It has been shown that hepatic cholesterol synthesis is associated with ATP binding cassette transporter G5 and G8 (ABCG5/8) activities. To test the hypothesis that genetic variation in ABCG5/8 might influence the plasma lipid response to statin therapy, we examined five nonsynonymous polymorphisms at the...
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