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Article

Granulosa Cell-Specific Inactivation of Follistatin Causes Female Fertility Defects

6 Jan 2004

Abstract excerpt

Follistatin plays an important role in female physiology by regulating FSH levels through blocking activin actions. Failure to regulate FSH has been implicated as a potential cause of premature ovarian failure. Premature ovarian failure is characterized by amenorrhea, infertility, and elevated gonadotropin levels in women under the age of 40. Because follistatin is essential for postnatal viability, we designed a...

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PMID: 14701941
DOI: 10.1210/me.2003-0301

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