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Article

Normal Prenatal but Arrested Postnatal Sexual Development of Luteinizing Hormone Receptor Knockout (LuRKO) Mice

2001-01-01

Abstract excerpt

To study further the role of gonadotropins in reproductive functions, we generated mice with LH receptor (LHR) knockout (LuRKO) by inactivating, through homologous recombination, exon 11 on the LHR gene. LuRKO males and females were born phenotypically normal, with testes, ovaries, and genital structures indistinguishable from their wild-type (WT) littermates. Postnatally, testicular growth and descent, and extern...

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Identifiers and source

Literature Corpus work
94281f6a-e26a-56bf-96e8-3d03b4dd2f14
DOI
10.1210/me.15.1.172
Open publication

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Normal Prenatal but Arrested Postnatal Sexual Development of Luteinizing Hormone Receptor Knockout (LuRKO) MiceDOI 10.1210/me.15.1.172
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