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Article

Conditional Fgfr1 Deletion in GnRH Neurons Leads to Minor Disruptions in the Reproductive Axis of Male and Female Mice.

Frontiers in endocrinology - 1 Jan 2020

Dela Cruz Cynthia, Horton Cassandra A, Sanders Kelsey N, Andersen Nathan D, Tsai Pei-San

Abstract excerpt

In humans and mice, inactivating mutations in fibroblast growth factor receptor 1 (Fgfr1) lead to gonadotropin-releasing hormone (GnRH) deficiency and a host of downstream reproductive disorders. It was unclear if Fgfr1 signaling directly upon GnRH neurons critically drove the establishment of a functional GnRH system. To answer this question, we generated a mouse model with a conditional deletion of Fgfr1 in...

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Identifiers

PMID: 33679600
DOI: 10.3389/fendo.2020.588459
PMCID: PMC7933197

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