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Article

Live Cell Imaging Demonstrates Multiple Routes Toward a STAT1 Gain-of-Function Phenotype.

Frontiers in immunology - 1 Jan 2020

Giovannozzi Simone, Lemmens Veerle, Hendrix Jelle, Gijsbers Rik, Schrijvers Rik

Abstract excerpt

Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations result in a primary immunodeficiency (PID) characterized typically by chronic mucocutaneous candidiasis (CMC), but a wider phenotypic range is reported and remains unexplained from a pathophysiological point-of-view. We hypothesized that different STAT1 GOF mutations may result in distinct molecular mechanisms, possibly...

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Identifiers

PMID: 32582194
DOI: 10.3389/fimmu.2020.01114
PMCID: PMC7296103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Live Cell Imaging Demonstrates Multiple Routes Toward a STAT1 Gain-of-Function Phenotype.PMID 32582194Read ↗

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