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Article

Structural basis for Rab GTPase activation by VPS9 domain exchange factors.

Nature structural & molecular biology - 1 May 2007

Delprato Anna, Lambright David G

Abstract excerpt

RABEX-5 and other exchange factors with VPS9 domains regulate endocytic trafficking through activation of the Rab family GTPases RAB5, RAB21 and RAB22. Here we report the crystal structure of the RABEX-5 catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway. The structure reveals how VPS9 domain exchange factors recognize Rab GTPase substrates, accelerate GDP...

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Source

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Identifiers

PMID: 17450153
DOI: 10.1038/nsmb1232
PMCID: PMC2254184

Genes

RAB21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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