Article
Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells.
Toxicology - 15 Jan 2004
Yoon Byung-Il, Hirabayashi Yoko, Kawasaki Yasushi, Tsuboi Isao, Ott Thomas, Kodama Yukio, Kanno Jun, Kim Dae-Yong, Willecke Klaus, Inoue Tohru
Abstract excerpt
The pulmonary pathogenesis triggered by benzene exposure was studied. Since the role of the connexin 32 (Cx32) gap junction protein in mouse pulmonary pathogenesis has been suggested, in the present study, we explored a possible role of Cx32 in benzene-induced pulmonary pathogenesis using the wild-type (WT) and Cx32 knockout (KO) mice. The mice were exposed to 300 ppm benzene by inhalation for 6 h per day, 5 days...
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