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Article

Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43

1 Jun 2004

Abstract excerpt

Gap junction intercellular communication capacity and connexin expression are reportedly decreased in human lung cancer. The mechanisms by which connexins, the gap junction proteins, act as tumor suppressors are unclear. In order to understand the involvement of connexins in tumorigenesis, we analyzed the effect of the heterologous deletion of Gja1 [the connexin43 (Cx43) gene] on the development of lung adenomas...

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PMID: 15166089
DOI: 10.1093/carcin/bgh193

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Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43PMID 15166089Read ↗

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