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Article

Benzene-Induced Aberrant miRNA Expression Profile in Hematopoietic Progenitor Cells in C57BL/6 Mice.

International journal of molecular sciences - 12 Nov 2015

Wei Haiyan, Zhang Juan, Tan Kehong, Sun Rongli, Yin Lihong, Pu Yuepu

Abstract excerpt

Benzene is a common environmental pollutant that causes hematological alterations. MicroRNAs (miRNAs) may play a role in benzene-induced hematotoxicity. In this study, C57BL/6 mice showed significant hematotoxicity after exposure to 150 mg/kg benzene for 4 weeks. Benzene exposure decreased not only the number of cells in peripheral blood but also hematopoietic progenitor cells in the bone marrow. Meanwhile, RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26569237
DOI: 10.3390/ijms161126001
PMCID: PMC4661859

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