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Article

The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.

Carcinogenesis - 1 Jul 1999

Moennikes O, Buchmann A, Ott T, Willecke1 K, Schwarz M

Abstract excerpt

Connexin32 (Cx32) is the major gap junctional protein in mouse liver. We have shown recently that the formation of liver tumours in Cx32-deficient mice is strongly increased in comparison with control wild-type mice, demonstrating that the deficiency in gap junctional communication has an enhancing effect on hepatocarcinogenesis. We have now compared the effect of Cx32 deficiency on liver carcinogenesis in two...

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Source

Identifiers

PMID: 10383916
DOI: 10.1093/carcin/20.7.1379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.PMID 10383916Read ↗

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Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.Semantic proximity Read ↗

Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.Semantic proximity Read ↗

Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Role of connexin32 and beta-catenin in tumor promotion in mouse liver.Semantic proximity Read ↗

Background lesions during a 24-month observation period in connexin 32-deficient mice.Semantic proximity Read ↗

Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals.Semantic proximity Read ↗

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.Semantic proximity Read ↗

Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32.Semantic proximity Read ↗

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