Article
ATM gene alterations in childhood acute lymphoblastic leukemias.
Human mutation - 1 May 2003
Gumy Pause Fabienne, Wacker Pierre, Maillet Philippe, Betts David, Sappino André-Pascal
Abstract excerpt
Hereditary ATM gene mutations cause ataxia-telangiectasia, a pleiotropic disorder associated with a high incidence of lymphoid malignancies. Acquired ATM alterations have been described in sporadic lymphoproliferative disorder suggesting that the ATM gene contributes to lymphomagenesis. To assess the prevalence of genomic ATM alterations in childhood acute lymphoblastic leukemias (ALL), we explored a series of 57...
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