Article
[Role of functional inactivation of p53 from MDM2 overexpression in hepatocarcinogenesis].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University - 28 Feb 2001
Luo Y L, Cheng R X, Feng D Y
Abstract excerpt
OBJECTIVE: This paper was to evaluate the role of p53 mutation, and p53 and MDM2 proteins expression in hepatocarcinogenesis. METHODS: Using streptavidin-peroxidase conjugation method (SP), the expression of p53 and MDM2 proteins was observed in 61 cases of primary hepatocarcinomas (HCC) and 59 cases of corresponding paracancerous tissue, among which p53 mutations in exons 5-8 were detected in 21 cases by...
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