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Article

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.

PLoS biology - 1 Dec 2003

Kondo Keiichi, Kim William Y, Lechpammer Mirna, Kaelin William G

Abstract excerpt

Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for degradation in the presence...

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Source

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Identifiers

PMID: 14691554
DOI: 10.1371/journal.pbio.0000083
PMCID: PMC300692

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.PMID 14691554Read ↗

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The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

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Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.Semantic proximity Read ↗

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