Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.

doi:10.1016/s1535-6108(02)00043-0

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Article

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.

Cancer cell - 1 Apr 2002

Kondo Keiichi, Klco Jeff, Nakamura Eijiro, Lechpammer Mirna, Kaelin William G

Abstract excerpt

Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product, pVHL, targets the heterodimeric transcription factor HIF for polyubiquitination, and restoration of pVHL function in VHL(-/-) renal carcinoma cells suppresses their ability to form tumors in nude mice. Here we show...

Topics

Animals
Blotting, Western
Carcinoma, Renal Cell
Cycloheximide
Down-Regulation
Genes, Tumor Suppressor
Glucose Transporter Type 1
Humans
Immunoenzyme Techniques
Kidney Neoplasms
Ligases
Mice
Mice, Nude
Monosaccharide Transport Proteins

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Mutation

Plasmids

Protein Synthesis Inhibitors

Retroviridae

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Open in PubMed

Identifiers

PMID: 12086860
DOI: 10.1016/s1535-6108(02)00043-0

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