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Article

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.

Cancer cell - 1 Apr 2002

Kondo Keiichi, Klco Jeff, Nakamura Eijiro, Lechpammer Mirna, Kaelin William G

Abstract excerpt

Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The VHL gene product, pVHL, targets the heterodimeric transcription factor HIF for polyubiquitination, and restoration of pVHL function in VHL(-/-) renal carcinoma cells suppresses their ability to form tumors in nude mice. Here we show...

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Source

Identifiers

PMID: 12086860
DOI: 10.1016/s1535-6108(02)00043-0

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.PMID 12086860Read ↗

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.Semantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.Semantic proximity Read ↗

The VHL tumor suppressor: master regulator of HIF.Semantic proximity Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.Semantic proximity Read ↗

The Positive Regulation of p53 by the Tumor Suppressor VHLSemantic proximity Read ↗

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.Semantic proximity Read ↗

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHLSemantic proximity Read ↗

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.Semantic proximity Read ↗

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