Article
The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005
Kaelin W G
Abstract excerpt
Biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is a common event in hereditary (von Hippel- Lindau disease) and sporadic hemangioblastomas and clear-cell renal carcinomas. Germ-line VHL mutations are also linked to some hereditary pheochromocytoma families. The VHL gene product, pVHL, interacts with a number of cellular proteins and is implicated in the control of angiogenesis,...
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