Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms

1 Feb 2018

Abstract excerpt

Hereditary hemochromatosis (HH), a disease marked by chronic iron overload from insufficient expression of the hormone hepcidin, is one of the most common genetic diseases. One form of HH (type III) results from mutations in transferrin receptor-2 (TfR2). TfR2 is postulated to be a part of signaling system that is capable of modulating hepcidin expression. However, the molecular details of TfR2's role in this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemoglobinopathies and Related Disorders
Share to Iron Metabolism and Disorders
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29388418
DOI: 10.1021/acs.biochem.8b00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing MechanismsPMID 29388418Read ↗

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.Semantic proximity Read ↗

Regulation of transferrin receptor 2 protein levels by transferrinSemantic proximity Read ↗

Hemochromatosis due to mutations in transferrin receptor 2.Semantic proximity Read ↗

Mechanism for multiple ligand recognition by the human transferrin receptor.Semantic proximity Read ↗

Analyses for binding of the transferrin family of proteins to the transferrin receptor 2.Semantic proximity Read ↗

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.Semantic proximity Read ↗

Role of TfR2-Y250X and TfR1- rs3817672 Single Nucleotide Polymorphism on Pathophysiology of Iron Deficiency Anemia.Semantic proximity Read ↗

Transferrin receptor 2: a new molecule in iron metabolism.Semantic proximity Read ↗

Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites.Semantic proximity Read ↗

JAK2 governs Transferrin Receptor 1 dynamics in mammalian cellsSemantic proximity Read ↗

Transferrin receptor 2 is frequently expressed in human cancer cell lines.Semantic proximity Read ↗

HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell SurfaceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.