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Article

Endosome sorting of beta 2-adrenoceptors is GRK5 independent.

British journal of pharmacology - 1 Jan 2004

Millman Ellen E, Rosenfeld Jennifer L, Vaughan David J, Nguyen Jacqueline, Dai WenPing, Alpizar-Foster Estrella, Clark Richard B, Knoll Brian J, Moore Robert H

Abstract excerpt

1. We have investigated the role of G protein-coupled receptor kinase 5 (GRK5) in the regulation of endosome sorting of human beta(2)-adrenoceptors. 2. Expressing GRK5 at a high level significantly increased the extent of internalization of wild-type beta(2)-adrenoceptors and of an internalization-defective mutant receptor, and increased receptor phosphorylation at serines 355 and 356 in the cytoplasmic tail. 3....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Adrenergic, beta-2

Source

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Identifiers

PMID: 14691047
DOI: 10.1038/sj.bjp.0705504
PMCID: PMC1574185

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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