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Article

Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.

Journal of neurochemistry - 1 Jan 2004

Li Wenxue, Hoffman Paul N, Stirling Wanda, Price Donald L, Lee Michael K

Abstract excerpt

Biochemical and genetic abnormalities of alpha-synuclein (alpha-Syn) are implicated in the pathogenesis of Parkinson's disease (PD) and other alpha-synucleinopathies. The abnormal intraneuronal accumulations of alpha-Syn in Lewy bodies (LBs) and Lewy neurites (LNs) have implicated defects in axonal transport of alpha-Syn in the alpha-synucleinopathies. Using human (Hu) alpha-Syn transgenic (Tg) mice, we have...

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Identifiers

PMID: 14690528
DOI: 10.1046/j.1471-4159.2003.02166.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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