Article
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.
The Journal of biological chemistry - 9 Oct 1998
Jensen P H, Nielsen M S, Jakes R, Dotti C G, Goedert M
Abstract excerpt
The presynaptic protein alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. First, two missense mutations A30P and A53T cause inheritable early onset Parkinson's disease in some families. Secondly, alpha-synuclein is present in Lewy bodies of affected nerve cells in th...
Topics
- Amino Acid Sequence
- Animals
- Axons
- Brain
- Female
- Lewy Bodies
- Mutation
- Nerve Tissue Proteins
- Optic Nerve
- Parkinson Disease
- Protein Binding
- Rats
- Recombinant Proteins
- Synucleins
- alpha-Synuclein