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Article

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

The Journal of biological chemistry - 9 Oct 1998

Jensen P H, Nielsen M S, Jakes R, Dotti C G, Goedert M

Abstract excerpt

The presynaptic protein alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. First, two missense mutations A30P and A53T cause inheritable early onset Parkinson's disease in some families. Secondly, alpha-synuclein is present in Lewy bodies of affected nerve cells in the predominant sporadic type of Parkinson's disease as well as in dementia with Lewy bodies. We demonstrate in the rat...

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Identifiers

PMID: 9756856
DOI: 10.1074/jbc.273.41.26292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.PMID 9756856Read ↗

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