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Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span

1 Dec 2003

Abstract excerpt

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane found in most cell types. Caveolin-1 is the principal protein component of caveolae membranes in nonmuscle cells. The recent development of Cav-1-deficient mice has allowed investigators to study the in vivo functional role of caveolae in the context of a whole animal model, as these mice lack morphologically detectable caveolae membrane...

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PMID: 14690422
DOI: 10.1021/bi0356348

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