Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

doi:10.1016/S0002-9440(10)61168-6

Article

Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

The American journal of pathology - 1 Jun 2002

Park David S, Woodman Scott E, Schubert William, Cohen Alex W, Frank Philippe G, Chandra Madhulika, Shirani Jamshid, Razani Babak, Tang Baiyu, Jelicks Linda A, Factor Stephen M, Weiss Louis M, Tanowitz Herbert B, Lisanti Michael P

Abstract excerpt

The caveolin gene family consists of caveolins 1, 2, and 3. Caveolins 1 and 2 are co-expressed in many cell types, such as endothelial cells, fibroblasts, smooth muscle cells and adipocytes, where they form a heteroligomeric complex. In contrast, the expression of caveolin-3 is muscle-specific. Thus, the expression of caveolin-1 is required for caveolae formation in non-muscle cells, while the expression of...

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Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

Abstract excerpt

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