Article
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
The Journal of biological chemistry - 12 Oct 2001
Razani B, Engelman J A, Wang X B, Schubert W, Zhang X L, Marks C B, Macaluso F, Russell R G, Li M, Pestell R G, Di Vizio D, Hou H, Kneitz B, Lagaud G, Christ G J, Edelmann W, Lisanti M P
Abstract excerpt
Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human cancer. Here, we created a caveolin-1 null (CAV-1 -/-) mouse model, using standard homologous recombination techniques, to assess the role of caveolin-1 in...
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