Does bafilomycin A 1 block the fusion of autophagosomes with lysosomes?

Abstract excerpt

Bafilomycin A(1) is a specific inhibitor of the vacuolar type H(+)-ATPase (V-ATPase) in cells, and inhibits the acidification of organelles containing this enzyme, such as lysosomes and endosomes. Recently, while editing and reviewing chapters on autophagy for Methods in Enzymology, we noticed repeated references to the effect of bafilomycin A(1) in blocking the fusion of autophagosomes with lysosomes. Of course...

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