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Article

Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.

American journal of physiology. Cell physiology - 1 Nov 2008

Krilov Lada, Nguyen Amy, Miyazaki Teruo, Unson Cecilia G, Bouscarel Bernard

Abstract excerpt

Glucagon receptor (GR) activity and expression are altered in several diseases, including Type 2 diabetes. Previously, we investigated the mechanism of GR desensitization and internalization. The present study focused on the fate of internalized GR. Using both hamster hepatocytes and human embryonic kidney (HEK)-293 cells, we showed that internalized GR recycled to the plasma membrane within 30-60 min following...

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Identifiers

PMID: 18787074
DOI: 10.1152/ajpcell.00240.2008
PMCID: PMC2584980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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