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Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas

24 Oct 2003

Abstract excerpt

Colorectal cancer is a multi-step process characterized by a sequence of genetic alterations in cell growth regulatory genes, such as the adenomatous polyposis coli, KRAS, p53 and DCC genes. In the present study mutation analysis was performed with SSCA/direct sequencing of the hot-spot regions in exons 11 and 15 for the BRAF gene and exons 1-2 for the KRAS gene in 130 primary colorectal cancer tumors and...

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PMID: 14688025
DOI: 10.1093/carcin/bgh049

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