Article
Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer.
Gut - 1 Sept 2009
Seth R, Crook S, Ibrahem S, Fadhil W, Jackson D, Ilyas M
Abstract excerpt
BACKGROUND AND AIMS: KRAS and BRAF mutations occur in colorectal cancers (CRCs) and are considered mutually exclusive methods of activating the RAS/RAF/MEK/ERK pathway. This pathway is a therapeutic target and KRAS mutation may predict tumour responsiveness. The purpose of this study was to inves...
Topics
- Animals
- Base Sequence
- Cell Line, Tumor
- Colorectal Neoplasms
- Conserved Sequence
- DNA Mutational Analysis
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Protein Isoforms
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)