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Article

High frequency of BRAF proto-oncogene hot spot mutation V600E in cohort of colorectal cancer patients from Ahvaz City, southwest Iran.

Pakistan journal of biological sciences : PJBS - 1 Apr 2014

Asl Javad Mohammadi, Almasi Shekoufeh, Tabatabaiefar Mohammad Amin

Abstract excerpt

Colorectal cancer (CRC) is one of the most common forms of cancer around the world. Sporadic CRCs are caused by accumulation of mutations in essential genes regulating normal proliferation and differentiation of cells. The proto-oncogene BRAF encoded by the BRAF gene is involved in the RAS/RAF/MAPK pathway of signal transduction during cell growth. Acquired mutations in BRAF have been found at high frequencies in...

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PMID: 25911848
DOI: 10.3923/pjbs.2014.565.569

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BRAF

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