Article
Mutational analysis of the ARAF gene in human cancers.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 2005
Lee Jong Woo, Soung Young Hwa, Kim Su Young, Park Won Sang, Nam Suk Woo, Min Woo Sung, Kim Sang Ho, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
Deregulation of RAS signal transduction has been implicated in the malignant growth of human cancer cells. The BRAF gene, encoding a RAF family member in the downstream pathway of RAS, is somatically mutated in a number of human cancers, raising the possibility that other RAF family members might be mutated in human cancers. In this study we analyzed the genomic DNAs for the detection of somatic mutations of the...
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