Article
A C. elegans CLIC-like protein required for intracellular tube formation and maintenance.
Science (New York, N.Y.) - 19 Dec 2003
Berry Katherine L, Bülow Hannes E, Hall David H, Hobert Oliver
Abstract excerpt
The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal...
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