Article
High fidelity SNP genotyping using sequence-specific primer elongation and fluorescence correlation spectroscopy.
Current pharmaceutical biotechnology - 1 Dec 2003
Hori K, Shin W S, Hemmi C, Toyo-oka T, Makino T
Abstract excerpt
Reliable, efficient and cost-effective modalities are urgently needed for mass screening of gene mutations. Previous reports have shown that SSCP or genechip methods require substantial time and monetary costs, thus limiting their appeal. Sequence Specific Primer Polymerase Chain Reaction (SSP-PCR) is a reliable and cost-effective method that utilizes the 3'-end discrimination properties of polymerase. However,...
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