Article
A base substitution in the interleukin-10 (IL-10) promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 2003
Jourdan-Le Saux C, Bollt O, Orozco C, Concepcion J, Yamaga K, Yamamoto F, Haymer D, Tam E K
Abstract excerpt
Interleukin 10 (IL-10) may play an important anti-inflammatory and immunoregulatory role in asthma. In this study, we investigated the role of a C to A substitution at position -627 of the IL-10 promoter, located in a necessary transcriptional region, which contains a number of putative transcriptional binding sites. The -627 nucleotide position is itself flanked by Sp-1 and ets-1 binding sites. We studied the...
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