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Article

Interleukin-10 and Transforming Growth Factor- β Promoter Polymorphisms in Allergies and Asthma

1 Dec 1998

Abstract excerpt

Interleukin-10 (IL-10) and transforming growth factor beta (TGF-beta) are inhibitory for B and T cells, IgE production, and mast cell proliferation, and they induce apoptosis in eosinophils. These cytokines are therefore candidate genes which could contribute to the development of asthma or allergies. We investigated the hypothesis that polymorphic nucleotides within the IL-10 and TGF-beta gene promoters would...

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PMID: 9847292
DOI: 10.1164/ajrccm.158.6.9804011

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