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Article

Interleukin‐10 gene promoter region polymorphism is associated with eosinophil count and circulating Immunoglobulin E in adult asthma

1 Jan 2003

Abstract excerpt

BACKGROUND: IL-10 has several functional effects relevant to asthma. It can modulate IgE production and induce apoptosis in eosinophils. Polymorphisms of IL-10 gene have been shown to affect IL-10 production. OBJECTIVE: To establish whether IL-10 polymorphisms are associated with asthma and phenotype-related characteristics. METHODS: The frequency of three single base exchange polymorphisms (at positions - 1082,...

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PMID: 12534553
DOI: 10.1046/j.1365-2222.2003.01577.x

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