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Article

Progress toward the evolution of an organism with an expanded genetic code.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 1999

Liu D R, Schultz P G

Abstract excerpt

Several significant steps have been completed toward a general method for the site-specific incorporation of unnatural amino acids into proteins in vivo. An "orthogonal" suppressor tRNA was derived from Saccharomyces cerevisiae tRNA2Gln. This yeast orthogonal tRNA is not a substrate in vitro or in vivo for any Escherichia coli aminoacyl-tRNA synthetase, including E. coli glutaminyl-tRNA synthetase (GlnRS), yet...

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Identifiers

PMID: 10220370
DOI: 10.1073/pnas.96.9.4780
PMCID: PMC21768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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