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Article

Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians.

Molecular genetics and metabolism - 1 Nov 2003

Wolford Johanna K, Colligan Peter B, Gruber Jonathan D, Bogardus Clifton

Abstract excerpt

Circulating levels of the cytokine interleukin 6 (IL-6) are elevated in obesity, correlate with body mass index (BMI), and predict the development of type 2 diabetes mellitus (T2DM). A promoter polymorphism in the IL6 gene is associated with obesity, altered levels of insulin sensitivity, and T2DM. IL-6 exerts its effects by binding to the IL-6 receptor (IL-6R) and levels of IL-6R have been correlated with BMI....

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Source

Identifiers

PMID: 14680981
DOI: 10.1016/j.ymgme.2003.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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