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Article

Apoptosis in transgenic mice expressing the P301L mutated form of human tau.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Ramalho Rita M, Viana Ricardo J S, Castro Rui E, Steer Clifford J, Low Walter C, Rodrigues Cecília M P

Abstract excerpt

The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer's disease (AD)-relevant cortical and limbic structures, deficits in spatial reference memory, and progression of neurofibrillary tangles (NFT). In this study, we examined the role of apoptosis in neuronal loss and associated tau pathology. The results showed that DNA fragmentation and caspase-3 activation are common in...

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Identifiers

PMID: 18368144
DOI: 10.2119/2007-00133.Ramalho
PMCID: PMC2274892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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