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Caspases, Apoptosis, and Alzheimer Disease: Causation, Correlation, and Confusion

1 Sept 2001

Abstract excerpt

Extensive neuron loss occurs in Alzheimer disease (AD) brain and some authors have speculated that dysregulation of apoptotic death pathways is etiologically responsible for the disease. Apoptosis is regulated in mammalian cells by a family of cysteine proteases called caspases. At least 7 different caspases (caspases 1, 2, 3, 6, 8, 9, and 12) have been implicated in regulating neuronal cell death in response to...

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PMID: 11556539
DOI: 10.1093/jnen/60.9.829

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