Article
Insertional mutation of a gene involved in growth regulation of the early mouse embryo.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 1992
Iannaccone P M, Zhou X, Khokha M, Boucher D, Kuehn M R
Abstract excerpt
A transgenic mouse strain derived from embryonic stem (ES) cells infected with multiple copies of a retroviral vector carries a recessive insertional mutation resulting in prenatal lethality. A detailed histological analysis of developing embryos has shown that the mutation results in hyperplasia...
Topics
- Animals
- Cell Count
- Embryo, Mammalian
- Embryonic and Fetal Development
- Genes
- Genotype
- Hyperplasia
- Image Processing, Computer-Assisted
- Mice
- Mice, Transgenic
- Mutagenesis, Insertional
- Mutation
- Phenotype
- Reference Values