Article
Insertional mutation of a gene involved in growth regulation of the early mouse embryo.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 1992
Iannaccone P M, Zhou X, Khokha M, Boucher D, Kuehn M R
Abstract excerpt
A transgenic mouse strain derived from embryonic stem (ES) cells infected with multiple copies of a retroviral vector carries a recessive insertional mutation resulting in prenatal lethality. A detailed histological analysis of developing embryos has shown that the mutation results in hyperplasia of both embryonic and extraembryonic ectoderm and failure of mesoderm formation in the egg cylinder stage embryo. The...
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