Article
Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation
1 Oct 2001
Abstract excerpt
The size of mammalian species involves the interaction of multiple genetic modifiers that control the timing and extent of growth mechanisms. Disruption of the paternal allele of the imprinted embryonic gene coding for insulin-like growth factor 2 (IGF2, Igf2(+m/-p)), results in viable mice that are 60% the weight of wild-type littermates. Differences in weight are first detected at embryonic day (E) 11, and the...
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