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Article

Structure and Ca2+ regulation of frog photoreceptor guanylate cyclase, ROS-GC1.

Molecular and cellular biochemistry - 1 Dec 2003

Subbaraya Iswari, Zhao Chong, Duda Teresa

Abstract excerpt

Rod outer segment membrane guanylate cyclase (ROS-GC) is a critical component of the vertebrate phototransduction machinery. In response to photoillumination, it senses a decline in free Ca(2+) levels from 500 to below 100 nM, becomes activated, and replenishes the depleted cyclic GMP pool to restore the dark state of the photoreceptor cell. It exists in two forms, ROS-GC1 and ROS-GC2. In outer segments, ROS-GCs...

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Identifiers

PMID: 14674678
DOI: 10.1023/a:1027311811807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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